Lipid synthesis from the liver in patients with psoriasis

Summary In psoriatic patients with hyperlipidemia we studied the hepatic lipidic synthesis from (1-¹⁴C)-acetate in human liver biopsy specimens in vitro by a thin-layer radio-chromatography.In psoriatics type IV (according to Fredrickson) a significant increase in (1-¹⁴C)-acetate hepatic incorporation especially into phospholipids (25%) and triglycerides (52%) was observed; in type IIb increased lipogenesis was accompanied by a greater hepatic incorporation of labelled acetate into phospholipids (24.5%), free cholesterol (44.4%) and triglycerides (29%).Abnormal lipid metabolism often coexists with glucose intolerance in psoriasis; no correlation between hyperinsulinemia and augmented (1-¹⁴C)-acetate incorporation into hepatic triglycerides was found.This paper was presented in part at the 57th National Congress of the Italian Society of Dermatology and Venereology