| 家兔肠缺血—再灌注损伤时脂质过氧化的变化及其意义 |
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| 引用本文： | 张硕森,李宏杰,景有伶,张连元,崔和勤,刘红,夏桂花. 家兔肠缺血—再灌注损伤时脂质过氧化的变化及其意义[J]. 天津医科大学学报, 1998, 0(4) |
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| 作者姓名： | 张硕森 李宏杰 景有伶 张连元 崔和勤 刘红 夏桂花 |
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| 作者单位： | 华北煤炭医学院病理生理教研室，华北煤炭医学院生物化学教研室，华北煤炭医学院医用化学教研室 |
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| 摘 要： | 目的：探讨肠缺血－再灌注（Ｉ／Ｒ）损伤时血浆及组织脂质过氧化的变化及其意义。方法：复制家兔肠Ｉ／Ｒ损伤模型，检测超氧化物歧化酶（ＳＯＤ）和黄嘌呤氧化酶（ＸＯ）活性及丙二醛（ＭＤＡ）含量。实验分为Ｉ／Ｒ损伤组及假手术（Ｓｈａｍ）对照组，并进行比较。结果：缺血前两组动物ＳＯＤ、ＸＯ及ＭＤＡ值均无统计学差异，Ｉ／Ｒ组再灌注后２ｈ与缺血前及Ｓｈａｍ组相比，ＳＯＤ活性显著下降，ＸＯ活性及ＭＤＡ含量明显增加（Ｐ〈０．０１）；此外，肺、肝等组织ＭＤＡ含量亦明显高于Ｓｈａｍ组（Ｐ〈０．０１）。结论：家兔肠Ｉ／Ｒ损伤时体内脂质过氧化过程加强，且在Ｉ／Ｒ损伤过程中起重要作用。
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| 关 键 词： | 缺血－再灌注损伤；超氧化物歧化酶；黄嘌呤氧化酶；丙二醛 |
CHANGES AND SIGNIFICANCE OF LIPID PEROXIDATION ON BOWEL ISCHEMIA REPERFUSION INJURY IN RABBITS |
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| Zhang Shuosen,Li Hongjie,Jing Youling,et al. CHANGES AND SIGNIFICANCE OF LIPID PEROXIDATION ON BOWEL ISCHEMIA REPERFUSION INJURY IN RABBITS[J]. Journal of Tianjin Medical University, 1998, 0(4) |
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| Authors: | Zhang Shuosen Li Hongjie Jing Youling et al |
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| Abstract: | Objective: To investigate the changes and significance of lipid peroxidation on bowel ischemia reperfusion(I/R)injury in rabbits Methods:The models of rabbit bowel I/R injury was made The changes of the activity of superoxide dismutase (SOD),xanthine oxidase(xo)and malondialdehyde(MDA) were determined Results: SOD activity was markedly decreased and XO activity and MDA content were markedly increased 2h after reperfusion Copared with before ischemia and sham group( P <0 01);The MDA content in lung and liver tissues etc were significantly higher than that in sham group( P <0 01) Conclusions: It is suggested that the lipid peroxidation process was increased in bowel I/R injury and might play an important role in I/R injury process |
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| Keywords: | Ischemia reperfusion injury Superoxide dismutase Xathine oxidase Malondialdehyde |
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