Monitoring of Bordetella isolates circulating in Saint Petersburg, Russia between 2001 and 2009 |
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Authors: | Natalia Kurova Elisabeth Njamkepo Delphine Brun Galina Tseneva Nicole Guiso |
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Institution: | a Institut Pasteur Epidemiology and Microbiology - Bacterial Respiratory Infections Laboratory, 14, Mira street, 197101 St. Petersburg, Russia;b Institut Pasteur, Molecular Prevention and Therapy of Human Infections, CNRS URA 3012, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France |
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Abstract: | Bordetella isolates in the Saint Petersburg region have been monitored since 1998. Over the past ten years, concomitant with the increase in pertussis whole-cell vaccine coverage, the incidence of whooping cough has decreased. However, this decrease exists only for Bordetella pertussis infections, as the incidence of Bordetella parapertussis confirmed cases has remained stable, suggesting that pertussis-vaccine-induced immunity is not protective against parapertussis, as expected. B. pertussis and B. parapertussis clinical isolates were analyzed using serotyping, immunoblotting, pulsed-field gel electrophoresis of chromosomal DNA (after digestion with XbaI) and sequencing of virulence genes. The bacterial population is now similar to that observed in other European countries. |
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Keywords: | Bordetella pertussis Bordetella parapertussis isolates St Petersburg Whooping cough |
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