| Abstract: | A case of a 72-year-old female with multiple syringomas of the clear cell type is reported. Ultrastructural observations revealed the following findings: 1) The tumor cells had the ordinary morphological features of usual syringoma cells. 2) The clear cells were rich in glycogen granules and various vacuoles. 3) Massive accumulations of glycogen granules surrounded by the unit membrane were occasionally observed. These electron microscopic findings were compatible with the light microscopic appearance of the clear cells. The tumor cells possessing characteristic clear cytoplasm can speculatively be regarded as altered syringoma cells with glycogen accumulation. The abnormal accumulation of the glycogen granules might be due to a kind of disorganized metabolism caused by diabetes mellitus in the syringoma cells. |
