女性肺癌对雌、孕激素受体的依赖及受体与预后的关系─附57例临床病理研究

本文用免疫组化法（改良ＰＡＰ法），检测５７例女性肺癌组织，５例正常肺组织和５例肺炎性假瘤组织（对照组）的雌激素受体（ＥＲ）和孕激素受体（ＰＲ）。结果证实女性肺癌组织内存在ＥＲ和ＰＲ，其阳性率分别为４２．１％和５４．４％，而对照组未发现ＥＲ和ＰＲ。ＥＲ、ＰＲ阳性的女肺癌术后５年生存率较阴性者高（（Ｐ＜０．０５）；ＥＲ、ＰＲ阳性的女性肺癌术后化疗效果较阴性者好（Ｐ＜０．０５），ＥＲ、ＰＲ的表达与肺癌的临床分期、瘤体大小、年龄、闭经与否无明显关系（Ｐ＞０．０５）。

The Dependence of Female Lung Cancer on Estrogen and Prgestogen Receptor and The Relation Between The Receptors and Prognosis

We have used immunohistochemical method(an improved PAP method) to determine estrogen receptor(ER) and progestogen receptor(PR) in 57 female cases with lung cancer tissue, 5 eases with normal lung tissue and 5 cases with lung inflammatory pseudotumor tissue. Result proved that positive rate in female lung cancer tissue with ER and PR were 42.1% and 54. 4% respectively. while no ER and PR in control group. 5-year survival rate of patients with ER and PR positive female lung cancer after operation was higher than those with negative ones(P<0. 05). 5-yearsurvival rate of ER and PR positive female lung cancer treated by chemotherapy after operation was also higher than those of negative ones(P<0. 05). The ER and PR expression was not obviously associated with climcal classifications of lung cancer, the type of tissue, the size of tumor, age nor amenorrhea of not(P<0. 05).