循环microRNA-499诊断AMI的Meta分析

目的 评价循环microRNA-499(miR-499)对急性心肌梗死(acute myocardial infarction,AMI)的诊断价值。方法 检索万方,中国知网,NCBI,PubmMed,EMBSASE数据库2015年5月以前发表的关于miR-499诊断AMI的文献。以QUADAS工具对文献进行质量评价,采用meta-disc1.4软件进行统计分析miR-499诊断AMI的总体敏感度、特异度、阳/阴性似然比和诊断优势比。以SROC曲线分析miR-499诊断AMI的总体性能。结果 该次meta分析共纳入10项研究,其中国人研究7项,SCI文献7项。miR-499诊断AMI总体诊断敏感度为83%(95%CI:0.81～0.85),总体诊断特异度为81%(95%CI:0.78～0.83),总体诊断阳性似然比为4.53(95%CI:3.12～6.58),总体诊断阴性似然比为0.22(95%CI:0.14～0.33),总体诊断优势比为22.73(95%CI:10.78～47.93)。综合SROC曲线下面积(AUC)为0.90,Q值为0.84。结论 miR-499对AMI具有较高的诊断价值。

Diagnostic Value of MicroRNA-499 for Acute Myocardial Infarction:a Meta-Analysis

Objective To evaluate the diagnostic value of microRNA-499(miR-499)levels in acute myocardial infarction(AMI)diagnosis.Methods Retrieve Articles,Wanfang,China Knowledge Network,NCBI PubmMed,EMBSASE database 2010～2015 years met the inclusion criteria published abroad in relation to miR-499 diagnosis ten cases of human AMI literature.The quality of the sudies was evaluated by QUADAS tools through a comprehensive analysis of the random effects model effect size,the use of meta-disc 1.4 software for statistical analysis software.Results Ten studies met the included criteria.The summary estimates for miR-499 diagnosis of MI sensitivity was 83%(95% CI,0.81～0.85), specificity of 81%(95% CI,0.78～0.83),positive predictive value of 4.53(95% CI,3.12～6.58),negative predictive value was 0.22(95% CI,0.14～0.33),diagnostic odds ratio 22.73(95% CI,10.78～47.93).The area under the curve(AUC)for miR-499 was 0.90 with Q value of 0.84.Conclusion MiR-499 has highdiagnostic value for acute myocardial infarction.