系统性红斑狼疮患者乙型肝炎病毒感染的分析研究

目的 了解并分析系统性红斑狼疮(systemic lupus erythematosus,SLE)患者乙型肝炎病毒(Hepatitis B virus,HBV)的感染状况。方法回顾性分析南京鼓楼医院2010年1月～2015年3月的866例SLE患者(SLE组)的临床资料; 并收集1 795例健康查体者(对照组)血清,使用酶联免疫吸附试验(ELISA)的方法检测乙肝病毒表面抗原(HBsAg),乙肝病毒表面抗体(HBsAb)及丙型肝炎(HCV)抗体。分析SLE组与对照组HBsAg,HBsAb及HCV抗体之间是否存在差异。结果 SLE患者中HBsAg阳性的共有17例,阳性率1.96%,对照组HBsAg阳性204例,阳性率为11.4%,两组之间差异具有统计学意义(χ²=67.81,P<0.000 1)。男性SLE患者阳性率5.26%,低于对照组的13.9%,差异具有统计学意义(χ²=4.58,P<0.05)。女性SLE患者HBsAg阳性率1.64%,也低于对照组的8.12%(χ²=35.65,P<0.0001)。在21～30,31～40和41～50岁三个年龄段中,SLE组HBsAg阳性率均低于对照组,差异均具有统计学意义(χ²分别为21.86,22.78和20.36; 均P<0.0001)。SLE患者中HBsAb阳性率与对照组差异无明显统计学意义(总:χ²=0.50,P=0.48; 男性:χ²=0.12,P=0.73; 女性:χ²=2.00,P=0.16)。结论 系统性红斑狼疮患者中乙型肝炎病毒感染率低于健康人群。

Prevalence of Hepatitis B Virus Infection in Systemic Lupus Erythematosus Patients

Objective To investigate the prevalence of Hepatitis B virus(HBV)infection in systemic lupus erythematosus(SLE)patients.Methods HBV and HCV serological tests performed in the GulouHospital Affiliated to Medical College of Nanjing University from January 2010to March 2015 were retrospectively investigated for analysis HBV and HCV infection rate.The clinical testing data of 866 SLE inpatients(SLE group)from January 2010 to March 2015 were retrospectively investigated for analysis HBV and HCVinfection rate.The serological tests performed in 1 795 health examination people(Control group)to estimate the HBV and HCV infection ratein general population using ELISA.Compare the difference of HBV/HCV infection rate between SLE group and Control group.Results In the SLE group,17 patients were HBsAg positive,the positive rate was 1.96%.In the control group HBsAgpostive 204 patients,the positive rate was 11.4%,there were significant differences between these two groups(χ²=67.81,P<0.0001).The HBsAg positive rate was lower in male SLE patients compared with controls(5.26% VS 13.9%,χ²=4.58,P<0.05).For the female SLE patients,the HBsAg positive rate was significantly lower than the control(1.64% VS 8.12%,χ²=35.65,P<0.0001).The HBsAg positive rate was lower in SLE group compared with control group among different age groups,and the difference was significant in 21～30,31～40 and 41～50 age group(χ²=21.86,22.78,20.36; all P<0.001).There had no statistical difference between SLE and control group for the HBsAbpositive rate(Total,χ²=0.50,P=0.48; Male,χ²=0.12,P=0.73; Female,χ²=2.00,P=0.16).Conclusion The prevalence of HBV infection in SLE patients was lower than general population.