高雄激素血症患者糖脂代谢情况的研究

目的 通过对高雄激素血症患者糖脂代谢情况的研究,分析高雄激素血症患者患心血管疾病的风险。方法 选取2013年4月～2014年7月118例育龄期妇女为研究对象,分别检测血清睾酮(T)、雌二醇(E2)、空腹血糖(FPG)、空腹胰岛素(FINS)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白(a)和体重指数(BMI),应用SPSS19.0软件,两独立样本t检验方法分组对各项检测结果进行分析。结果 高雄激素血症组血清BMI,T,FPG,HOMA-IR,TG明显高于正常对照组(P<0.05),而两组间E2,TC,HDL-C,LDL-C和LP(a)差异无统计学意义(P>0.05)。将高雄激素血症组按病因分为PCOS高雄激素血症组与非PCOS高雄激素血症组,两组BMI,T,E2,FPG,HOMA-IR,TG,TC,HDL-C,LDL-C和LP(a)差异均无统计学意义(P>0.05)。根据中国成人肥胖定义,将78例高雄激素血症患者分为BMI≥24 kg/m²的超重肥胖组和BMI<24 kg/m²的正常体重组,超重肥胖组BMI,T,FPG,HOMA-IR,TG,TC,LDL-C和LP(a)明显高于正常体重组,HDL-C明显低于正常体重组,差异有统计学意义(P<0.05),E2差异无统计学意义(P>0.05)。结论 研究高雄激素血症与糖脂代谢的相关性可以对高雄激素血症代谢异常患者实施指导生活方式和药物治疗,预防心血管疾病的发生。

Study on Metabolism of Glucose and Lipid in Patients with Hyperandrogenism

Objective To study metabolism of glucose and lipidin patients with hyperandrogenism and analyze the risk of their cardiovascular disease.Methods Object of study:firstly,choosed 118cases of women of reproductive age from April 2013 to July 2014.Then detected their serum Testosterone(T),Estradiol(E2),fasting plasma Glucose(FPG),fasting plasma insulin(FINS),triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipoprotein(a),body mass index(BMI).Finally,divided them into different groups and analyzed the results using SOSS19.0 software and two independentsamples t-test statistical method.Results BMI,T,FPG,HOMA-IR and TG were significantly more higher(P<0.05)in the group ofhyperandr-ogenism than in the group of normal control.However,E2,TC,HDL-C,LDL-C and LP(a)had no significant difference(P>0.05)in statistics between the group of hyperandrogenism and the group of normal control.Hyperandr-ogenism group was divided into PCOS group and non-PCOS group according to etiology.In those two groups,BMI,T,E2,FPG,HOMA-IR,TG,TC,HDL-C,LDL-C and LP(a)had no significant difference in statistics(P>0.05).According to the definition of obesity adults in china,78 patients with hyperandrogenismwere divided into 2 group,one with BMI normal(BMI<24 kg/m²)and the othergroup with overweight and obesity(BMI≥24 kg/m²).In group with overweight and obesity,BMI,T,FPG,HOMA-IR,TG,TC,LDL-C and LP(a)were significantlyhigher than the group with BMI normal(P<0.05),moreover,HDL-C was significantly lower than the group normal(P<0.05).E2 had no significant difference in statistics between the two groups(P>0.05).ConclusionInvestigation of the relation between hyp-erandrogenism and metabolism of glucose and lipid,can not only practically guide life style and drug therapy,but also prevent cardio-vascular disease.