| 浊度法测定红霉素类抗生素制剂的抗菌活性 |
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| 引用本文： | 高燕霞,姜建国,韩彬. 浊度法测定红霉素类抗生素制剂的抗菌活性[J]. 中国药业, 2010, 19(14): 40-42 |
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| 作者姓名： | 高燕霞 姜建国 韩彬 |
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| 作者单位： | 河北省药品检验所,河北,石家庄,050011 |
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| 基金项目： | 2006年河北省科技厅资助课题 |
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| 摘 要： | 目的建立测定红霉素、琥乙红霉素及依托红霉素活性的浊度法,并对其进行考察评价。方法以金黄色葡萄球菌为试验菌,加菌量为1.0%～1.2%（V/V）,（37±0.5）℃培养3～4 h后测定。结果红霉素抗生素线性浓度为0.08～0.8 IU/mL。结论该方法灵敏、快速、影响因素较少,可作为测定、评价红霉素、琥乙红霉素及依托红霉素活性的方法。
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| 关 键 词： | 抗菌活性 浊度法 红霉素 琥乙红霉素 依托红霉素 |
Evaluation of Antimicrobial Activity of Erythromycins Preparation by Turbidimetric Method |
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| Gao Yanxia,Jiang Jianguo,Han Bin. Evaluation of Antimicrobial Activity of Erythromycins Preparation by Turbidimetric Method[J]. China Pharmaceuticals, 2010, 19(14): 40-42 |
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| Authors: | Gao Yanxia Jiang Jianguo Han Bin |
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| Affiliation: | (Hebei Provincial Institute for Drug Control,Shijiazhuang,Hebei,China 050011) |
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| Abstract: | Objective To establish a turbidimetric method for determining the antimicrobial activity of erythromycin and erythromycin ethylsuc-cinate and erythromycin estolate.Methods The test organism was Staphylococcus aureus and cultured with fresh medium（pH = 7.0）.Staphylococcus aureus inoculated with a 1.0%-1.2%（V/V） ratio was cultured at（37 ± 0.5）℃ for about 3-4 h.Results The linear range of erythromycin was 0.08-0.8 IU/mL.Conclusion The method is sensitive,rapid with less influencing factors,which is feasible to appraise the antimicrobial activity of erythromycin,erythromycin ethylsuccinate and erythromycin estolate. |
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| Keywords: | antimicrobial activity turbidimetric method erythromycin erythromycin ethylsuccinate erythromycin estolate |
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