分枝杆菌多糖治疗小儿反复呼吸道感染的临床观察

对２３例反复呼吸道感染小儿采用分枝杆菌多糖（ＭＰＳ）系统治疗观察，检测用药前后Ｔ细胞亚群ＣＤ_４、ＣＤ_８及ＣＤ_４／ＣＤ_８之变化，并与健康对照组相比，同时进行临床疗效判断。结果患儿组治疗前ＣＤ_４及ＣＤ_４／ＣＤ_８均较对照组降低。经ＭＰＳ治疗后两者均明显上升，且与健康对照组无显著差异。临床疗效判断显效和有效２２例，无效１例。提示反复呼吸道感染小儿Ｔ细胞免疫功能受到抑制，ＭＰＳ对改善其细胞免疫功能状态有一定作用。

An Observation of Mycobacterial Polysaccharides (MPS) on Treatment of Repeated Respiratory Tract infection in Children

51 cases of repeated respiratory tract infection patient were treated with MPS.20 cases of normal children were selected as control group.T-cell subgroup(CD)in peripheral blood were examined for the children of 2 groups.The effects of MPS were evaluated on the patients'clinical changes and the results of CD change.The conclusion is as follows:①The levels of CD₄ and CD₄/CD₈ in the patient group were lower than that of the normal children of control group before treatment(P<0.01),indicating that the function of cellular immunity in susceptible children in low. ②Reexamination of CD for 31 patients after treatment with MPS revealed that there is no significant difference for CD₃,CD₄,CD₄/CD₈ as compared with control group(P>0.05),indicating that MPS could improve the function for the cellular immunity of the patients. ③Clinically among 51 cases of patient,21 cases were very much improved,indicating MPS is significantly effective in the treatment of RRI and 28 cases were improved,indicating MPS is effective making a total effective rate 96% .