|
|||||
|
|
| DNA修复与顺铂耐药 | |
| 引用本文： | 夏莹,周东波,胡成平. DNA修复与顺铂耐药[J]. 国际病理科学与临床杂志, 2006, 26(4): 16-339 |
| 作者姓名： | 夏莹 周东波 胡成平 |
| 作者单位： | 1. 中南大学湘雅医院呼吸科,长沙,410008;长沙市中心医院胸科三病室,长沙,410004 2. 中南大学湘雅医院呼吸科,长沙,410008 |
| 摘 要： | 顺铂的主要药理机制是损伤细胞DNA，肿瘤细胞DNA修复能力增强则会导致其对顺铂耐药。目前研究发现，DNA修复途径中的核苷酸切除修复、错配修复、碱基切除修复均与顺铂耐药有关，核苷酸切除修复为其中最为重要的途径。 |
| 关 键 词： | DNA修复 耐药 核苷酸切除修 |
| 文章编号： | 1673-2588(2006)04-0336-04 |
| 收稿时间： | 2006-02-25 |
| 修稿时间： | 2006-02-25 |
DNA repair and resistance of lung cancer to cisplatin |
|
| XIA Ying,ZHOU Dong-bo,HU Cheng-ping. DNA repair and resistance of lung cancer to cisplatin[J]. Journal of International Pathology and Clinical Medicine, 2006, 26(4): 16-339 | |
| Authors: | XIA Ying ZHOU Dong-bo HU Cheng-ping |
| Affiliation: | 1.Department of Respiratory of Xiangya Hospital, Central South University, Changsha 410008； 2.Thoracic General Ward 3, Changsha Central Hospital, Changsha 410004， China |
| Abstract: | The main mechanism of cisplatin is tumor cells death by damaging the DNA.The resistance to cisplatin is associated with the cell's increased ability of DNA repair.DNA repair mechanisms include nucleotide excision repair,mismatch repair and base exision repair which all associate with cisplatin resistance,and nucleotide excision repair is the main mechanism responsible for it. |
| Keywords: | DNA repair drug resistance nucleotide excision repair |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《国际病理科学与临床杂志》浏览原始摘要信息 | |
| 点击此处可从《国际病理科学与临床杂志》下载免费的PDF全文 | |