| 骨水泥掺入常用化疗药的释放及活性 |
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| 引用本文： | 孙诚,柳霞,徐晓明. 骨水泥掺入常用化疗药的释放及活性[J]. 空军总医院学报, 2004, 20(1): 23-24 |
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| 作者姓名： | 孙诚 柳霞 徐晓明 |
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| 作者单位： | 空军总医院放射科,北京,100036;空军总医院理疗科,北京,100036 |
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| 摘 要： | 目的 明确常用化疗药丝裂霉素、长春新碱和5-F尿嘧啶掺入骨水泥后的释放及活性。方法 采用洗提法和MTT法测量药物的释放及活性。结果 三种药物均可从骨水泥中释放并具有杀伤肿瘤细胞效应。结论 骨水泥携带抗癌药具有抗肿瘤效应。
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| 关 键 词： | 骨粘合剂 丝裂毒素类 长春新碱 尿嘧啶 |
| 文章编号： | 1009-2811(2004)01-23-02 |
| 修稿时间： | 2003-10-24 |
The release and activity of chemotherapy agents from bone cement |
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| SUN Cheng,LIU Xia,XU Xiao-ming. The release and activity of chemotherapy agents from bone cement[J]. Journal of General Hospital of Air Force,PLA, 2004, 20(1): 23-24 |
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| Authors: | SUN Cheng LIU Xia XU Xiao-ming |
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| Abstract: | Objective To determine the release of mitomycin C, vincristine sulfate and 5-flauouracil mixed with bone cement and the anti-cancer activity of the released drugs. Methods The release of drugs was studied by elution test. The anti-cancer activity of drugs was assessed by MTT method. Results The release of those drugs can be detected within 10-14 days and their anti-cancer activity lasted about 12 or 24 hours on MTT method. The more volume of those drugs mixed with bone cement is, the more the release and anti-cancer activity is. Conclusion Those drugs released from bone cement have the effect of anti-cancer. |
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| Keywords: | Bone cemetns Mitomycins Vincristine Uracil |
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