| 新辅助化疗对乳腺癌雌孕激素受体表达的影响 |
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| 引用本文： | Wang S,Zhang JQ,Qiao XM,Yang DQ,Tong FZ,Liu HJ. 新辅助化疗对乳腺癌雌孕激素受体表达的影响[J]. 中华外科杂志, 2005, 43(15): 1011-1013 |
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| 作者姓名： | Wang S Zhang JQ Qiao XM Yang DQ Tong FZ Liu HJ |
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| 作者单位： | 100044,北京大学人民医院乳腺外科 |
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| 摘 要： | 目的探讨新辅助化疗对乳腺癌雌孕激素受体表达的影响。方法应用免疫组化方法检测31例乳腺癌患者新辅助化疗前后的雌孕激素受体表达情况。结果31例患者中13例（41．9％）雌激素受体表达水平升高,其中7例（22．6％）由阴性转为阳性;10例（32．3％）孕激素受体表达水平升高,其中7例（22．6％）由阴性转为阳性;8例（25．8％）雌孕激素受体表达同时升高,其中4例（12．9％）由雌孕激素受体双阴性转变为雌孕激素受体双阳性。结论新辅助化疗影响雌孕激素受体的表达;新辅助化疗后应重新检测雌孕激素受体,为后续治疗和判断预后提供指导。
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| 关 键 词： | 新辅助化疗 乳腺癌 雌孕激素 受体表达 免疫组织化学 |
| 收稿时间： | 2004-10-13 |
| 修稿时间： | 2004-10-13 |
The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression in breast carcinoma |
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| Wang Shu,Zhang Jia-qing,Qiao Xin-min,Yang De-qi,Tong Fu-zhong,Liu Hong-jun. The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression in breast carcinoma[J]. Chinese Journal of Surgery, 2005, 43(15): 1011-1013 |
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| Authors: | Wang Shu Zhang Jia-qing Qiao Xin-min Yang De-qi Tong Fu-zhong Liu Hong-jun |
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| Affiliation: | Department of Breast, People's Hospital, Peking University, Beijing 100044, China. dr.wangshu@263.net |
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| Abstract: | Objective To investigate the effect of neoadjuvant chemotherapy on estrogen receptor (ER) and progesterone receptor (PR) expression in breast carcinoma. Methods Samples were obtained from 31 patients with breast carcinoma who received neo-adjuvant chemotherapy, ER or PR expressions were analyzed in preoperative core biopsies and final surgical specimens. Results ER level was up-regulated in 13(41.9%) out of 31cases, PR level was up-regulated in 10(32.3%).Both ER level and PR level were up-regulated in 8(25.8%) out of 31 cases. Conclusions Neoadjuvant chemotherapy may impact the hormone receptor status, ER and PR expression re-analysis in final surgical specimens is recommended. |
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| Keywords: | Breast neoplasms Receptors, estrogen Progestation hormones Immunohistochemistry Neo-adjuvant chemotherapy |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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