上皮-间质转化相关的信号传导通路 |
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引用本文: | 李余发,梁莉,丁彦青. 上皮-间质转化相关的信号传导通路[J]. 国际肿瘤学杂志, 2009, 36(2). DOI: 10.3760/cma.j.issn.1673-422X.2009.02.001 |
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作者姓名: | 李余发 梁莉 丁彦青 |
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作者单位: | 南方医科大学病理教研室,广州,510515;南方医科大学病理教研室,广州,510515;南方医科大学病理教研室,广州,510515 |
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摘 要: | 上皮-间质转化(EMT)在胚胎发育中是一个高度保守的细胞程序,它与肿瘤的浸润转移密切相关.参与这一过程的细胞内信号转导途经主要有转化生长因子(TGF)-β途径、Rho家族激酶、Hedgehog通路、Wnt通路、Notch通路、转录因子等.
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关 键 词: | 信号传导 表型 上皮细胞 |
Epithelial-mesenchymal transformation related signaling pathway |
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Abstract: | Eipthelial-mesenchymal transformation in embryonic development is a highly conservative procedure,It is highly correlated with tumor invasion and metastasis.Several signaling pathways are involved in the cell phenotype transition,such as TGF-β pathway,Rho kinase family,Hedgehog pathway,Wnt pathway,Notch pathway and transcription factors. |
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Keywords: | Signal transduction Phenotype Epithelial cells |
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