福定碱的抗胆碱酷酶作用

福定碱对人真性胆碱酯酶(ChE)的抑制是假性ChE的55386倍,对假性ChE的作用有显著的种属差异,它对真性ChE的抑制强度由强至弱是人、狗、家兔、猫、大鼠和小鼠;对假性ChE的作用强度依次是家兔、大鼠、狗、猫、小鼠和人。体内给药对脑和血液ChE都有明显的抑制作用,抑制ChE的活力可自动恢复,但所需时间较长。

Anti-Cholinesterase Activity of Fordine

The inhibitory effect of fordine on human true cholinesterase (ChE) was found to be 55386 times larger than on pseudo ChE in vitro. There was a marked difference in the inhibition of fordine on pseudo ChE of different species. The order of the decrease of potency of fordine on true ChE of different species was man, dog, rabbit, cat, rat and mouse. The order of the decrease of potency on pseudo ChE was rabbit, rat, dog, cat, mouse and man. In vivo, it was shown that ChE in blood and brain was strongly inhibited by fordine, and the duration of the inhibitory action was comparatively long. The ChE activity inhibited by fordine may recover spoutaneously.