急性脑梗死患者血清细胞黏附分子-1和C-反应蛋白浓度变化

目的探讨急性脑梗死患者血清细胞黏附分子-1(ICAM-1)和C-反应蛋白(CRP)浓度的变化及其与缺血后脑损伤程度的关系。方法将急性脑梗死患者按梗死容积的大小分为3组,分别在就诊时(距发病不到72h)、距发病1、4周时采集血标本,检测血清ICAM-1、CRP浓度,并收集同期门诊体检的健康人群作为对照组。结果(1)在脑梗死发病早期,患者血清ICAM-1、CRP浓度与脑梗死容积呈正相关,(P<0.05)。(2)大容积梗死组及中等容积梗死组在发病1周时与发病早期相比较两指标均明显下降,恢复期与发病1周时比较仍有明显降低(P<0.01)。而小容积梗死组只有CRP水平较前下降(P<0.05),ICAM-1浓度在整个病程中变化不明显。(3)脑梗死组在发病72h内、1周时两指标均较对照组高,而到恢复期时只有CRP与对照组比较有显著性差异。结论ICAM-1、CRP浓度与缺血性脑卒中的梗死容积密切相关,其变化反映脑梗死的发展演变过程。

Changes of the levels of intercellular adhesion molecule-1 and C reactive protein in serum of acute cerebral infarction patients

Objectives To explore changes of the levels of intercellular adhesion molecule-1(ICAM-1)and C reactive protein(CRP)in blood serum of acute cerebral infarction patients,and to find the relationship between these changes and brain injury after ischemia.Methods According to the bulk of infarction,acute cerebral infarction patients were divided into three groups.The levels of ICAM-1 and CRP in serum were examined at the time of admission(within 72 h from the onset),at the end of the 1st week and the 4th week after the episode.At the same time,the data of healthy persons were collected as control group.Results(1)Early after the onset of cerebral infarction,the levels of ICAM-1 and CRP in serum had positive correlation with the bulk of infarction(P<0.05).(2)The levels of ICAM-1 and CRP in serum of big and middle-sized bulk group descended significantly through the whole course(P<0.01)compared with those early after the onset;but in the small bulk group,only CRP descended significantly through the whole course(P<0.05).(3)Compared with the control group,ICAM-1 and CRP levels of the cerebral infarction group were significantly higher in acute stage(within one week from the onset).In the stage of recovery,only CRP was significantly different from the control group(P<0.05).Conclusion ICAM-1 and CRP levels have obvious relationship with the bulk of infarction and can reflect the development of cerebral infarction.