Two-year changes in health-related quality of life in gastric bypass patients compared with severely obese controls |
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| Authors: | Ronette L Kolotkin Ross D Crosby Richard E Gress Steven C Hunt Ted D Adams |
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| Institution: | 1. Obesity and Quality of Life Consulting, Durham, North Carolina;2. Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina;3. Neuropsychiatric Research Institute, Fargo, North Dakota;4. Department of Neuroscience, University of North Dakota School of Medicine, Fargo, North Dakota;5. Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, Utah;1. Tribomaterials Group, Department of Engineering Sciences, Uppsala University, PO Box 534, SE-751 21 Uppsala, Sweden;2. Department of Chemistry - Ångström Laboratory, Uppsala University, PO Box 538, SE-751 21 Uppsala, Sweden;3. Thin Films Group, Department of Engineering Sciences, Uppsala University, PO Box 534, SE-751 21 Uppsala, Sweden;1. Nursing Institute and Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio;2. Emergency Medicine and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan;3. Heart Failure Clinic, Morristown Medical Center, Morristown, New Jersey;4. Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio;1. Department of Medicine, Sarder Patel Medical College and Associated Group of Hospitals, Bikaner, India;2. Department of Medicine, Fortis Escorts Hospital, Jaipur, India;3. Jaipur Diabetes Research Centre, Jaipur, India;4. Department of Community Medicine, Assam Medical College, Dibrugarh, India;6. University of California San Francisco, Fresno, CA, USA;1. Department of Neurology, Columbia University Medical Center, New York, NY, USA;2. Taub Institute for Research on Alzheimer''s Disease and the Aging Brain, Columbia University, New York, NY, USA;1. Department of Radiology, University of Utah Health Sciences Center, Salt Lake City, UT, USA;2. Department of Internal Medicine, Vanderbilt University, Medical Center North, Nashville, TN, USA;3. Cibiem, Inc., Hayward, CA, USA;4. Department of Medicine and Cardiology, The Ohio State University, Columbus, OH, USA;1. Undergraduate School of Informatics and Mathematical Science, Faculty of Engineering, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501 Japan;2. Graduate School of Informatics, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501 Japan |
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| Abstract: | BackgroundFew weight loss surgery trials have evaluated the changes in health-related quality of life (HRQOL) relative to obese individuals not participating in weight loss interventions. In a prospective study at a bariatric surgery practice, we evaluated the 2-year changes in HRQOL in gastric bypass patients compared with 2 severely obese groups who did not undergo surgical weight loss.MethodsA total of 308 gastric bypass patients were compared with 253 individuals who sought but did not undergo gastric bypass and 272 population-based obese individuals using the weight-related (Impact of Weight on Quality of Life-Lite) and general (Medical Outcomes Study 36-item Short-Form Health Survey) HRQOL questionnaires at baseline and 2 years of follow-up.ResultsThe percentage of weight loss was 34.2% for the gastric bypass and 1.4% for the no gastric bypass groups, with a .5% gain for population-based obese group. Both measures of HRQOL showed greater improvements for the gastric bypass group, even after controlling for baseline differences. Effect sizes for changes in physical and weight-related HRQOL were very large for gastric bypass, but small to medium for the 2 comparison groups. Effect sizes for changes in the psychosocial aspects of HRQOL were moderate to very large for gastric bypass, but small for the 2 comparison groups. Of the gastric bypass patients, 97% had meaningful improvements in the Impact of Weight on Quality of Life-Lite total score compared with 43% of the no gastric bypass group and 30% of the population-based obese group.ConclusionDramatic improvements had occurred in weight-related and physical HRQOL for gastric bypass patients at 2 years after surgery compared with 2 severely obese groups who had not undergone surgery. These results support the effectiveness of gastric bypass surgery in improving patients' HRQOL. |
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