白细胞介素-16启动子区基因多态性与江西汉族人群哮喘的关系 |
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引用本文: | 陈小文,杨慧,刘玉琳,吴照芳,崔晓民. 白细胞介素-16启动子区基因多态性与江西汉族人群哮喘的关系[J]. 广东医学, 2008, 29(4): 597-599 |
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作者姓名: | 陈小文 杨慧 刘玉琳 吴照芳 崔晓民 |
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作者单位: | 南昌大学基础医学院变态反应疾病研究室,南昌,330006;南昌大学基础医学院变态反应疾病研究室,南昌,330006;南昌大学基础医学院变态反应疾病研究室,南昌,330006;南昌大学基础医学院变态反应疾病研究室,南昌,330006;南昌大学基础医学院变态反应疾病研究室,南昌,330006 |
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摘 要: | [[摘要] 目的 探讨IL-16启动子区-295T/C基因多态性与哮喘的关系。方法 采用等位基因特异性聚合酶链反应(AS-PCR)及测序方法,检测76例哮喘患者,73例正常人IL-16启动子区-295T/C基因型。结果 哮喘组人群IL-16 启动子区(-295T/C )TT,TC,CC基因频率分别为61.8%,32.9%,5.3% ;T,C等位基因频率分别为78.3%、21.7%。正常组人群IL-16启动子区(-295T/C )TT,TC,CC基因型频率分别为61.6%,35.6%,2.8%;T,C等位基因频率分别为79.5%,20.5%。两组比较差异无显著性(p>0.05)。结论 江西汉族正常人群IL-16启动子区-295T/C基因多态性分布频率与日本人群相似;IL-16启动子区-295T/C基因多态性与江西汉族人群哮喘无相关性。[关键词] 白细胞介素-16 基因多态性 哮喘
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关 键 词: | 白细胞介素-16 基因多态性 哮喘 |
修稿时间: | 2007-11-05 |
Association of a promoter polymorphism in the Interleukin-16 gene with asthma in Han nationality in Jiangxi Chinese population |
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Abstract: | Objective: To investigate the association between the -295T/C promoter polymorphism in the IL-16 gene and asthma in Han nationality in Jiangxi Chinese population. Methods: Allele Specific-PCR and Sequence Analysis were used to establish the genotype and allele frequencies of the -295T/C promoter polymorphism in Han nationality in Jiangxi Chinese population, which included 76 asthmatic patients, 73 nonasthmatic controls. Results: In asthmatic patients, the genotype frequencies were 61.8%(TT), 32.9%(TC), 5.3%(CC), and the allele frequencies were 78.3%(T), 21.7%(C). While in nonasthmatic controls, the genotype frequencies were 61.6%(TT) , 35.6%(TC), 2.8%(CC), and the allele frequencies were 79.5%(T), 20.5%(C). No significant difference in the genotype and allele frequencies of IL-16 gene polymorphism was found between asthmatic patients and nonasthmatic controls (p>0.05). Conclusion: The genotype and allele frequencies of the IL-16 -295T/C gene polymorphism in healthy population of the Hans from Jiangxi province of China were similar to those in Japanese population; The IL-16 -295T/C promoter polymorphism is not associated with asthma in the Hans from Jiangxi province of China. |
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