| 大鼠杏仁核点燃癫痫模型丘脑中线核群中c－fos蛋白的表达 |
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| 引用本文： | 史焕昌,吴若秋,刘健,孙业忠,刘窗溪,杨华,韩国强.大鼠杏仁核点燃癫痫模型丘脑中线核群中c－fos蛋白的表达[J].中国临床神经科学,2003,11(3):254-257. |
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| 作者姓名： | 史焕昌 吴若秋 刘健 孙业忠 刘窗溪 杨华 韩国强 |
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| 作者单位： | 1. 天津市人民医院,第二中心医院,神经外科,300120
2. 贵阳医学院附属医院神经外科,550004 |
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| 摘 要： | 目的探讨丘脑中线核群与颞叶癫癎的病理生理联系.方法采用免疫组化方法,在杏仁核点燃的大鼠癫癎模型上,观察丘脑有关核群c-fos蛋白表达细胞分布情况,用c-fos阳性细胞密度作定量研究指标.结果在杏仁核点燃的大鼠,癫癎发作达到4～5级时,丘脑中线核群的室旁核、菱形核、连结核以及丘脑背内侧核均有显著的c-fos蛋白表达.结论丘脑中线核群参与颞叶癫癎的传播过程.
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| 关 键 词： | 癫癎 点燃 丘脑中线核群 免疫组化 |
| 文章编号： | 1008-0678(2003)03-0254-04 |
| 修稿时间： | 2003年2月28日 |
Expression of Oncogene c-fos in Amygala Kinding Induces Generalized Epilepsy in Midline Thalamus Nuclei of the Rats |
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| Abstract: | Aim:To observe expression of oncogene c-fos in Amygala kinding induces generalized epilepsy in midline thalamus nuclei of the rat. Methods:Using immunohistochemical technique to investigate the expression of oncogene c-fos in 6 cases of normal thalamus of the rat. 30 cases Amygala kinding induces generalized epilepsy in midline thalamus muclei of the rat, respecfively. Results:There was lower expression of c-fos in normal midline thalamus nuclei of the rat. There existed singnificant overexpression of c-fos in Amygala kinding induces generalized epilepsy in midline thalamus nuclei of the rat. the positive rate was 50% in the medial dorsal nuclei, 44% in the reuniens nuclei and 43.5% in the rhomboid nuclei, respectively. Conclusion:The midline thalamic nuclei may invoved in the pathophysiology of Amygala kinding induces generalized epilepsy. |
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| Keywords: | epilepsy amygala kinding midline thalamic nuclei oncogen c-fos immunohistochemistry |
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