| 内含子miRNA反馈调节宿主基因的表达与功能研究进展 |
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| 引用本文： | 黄宝春,曹国军,邵宁生.内含子miRNA反馈调节宿主基因的表达与功能研究进展[J].军事医学科学院院刊,2009,33(6):580-582. |
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| 作者姓名： | 黄宝春 曹国军 邵宁生 |
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| 作者单位： | 军事医学科学院基础医学研究所,北京,100850 |
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| 基金项目： | 国家重点基础研究发展规划，国家自然基金面上项目 |
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| 摘 要： | miRNA是近年来发现的一类重要的基因表达调控因子。研究发现,许多miRNA位于编码蛋白基因（宿主基因）的内含子中,称为内含子miRNA。现有的证据表明,大多数内含子miRNA和它们的宿主基因表达一致,提示这些内含子miRNA参与宿主基因在功能和表达上的调控,本文就这方面的最新研究进展做一综述。
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| 关 键 词： | miRNA 内含子 宿主基因 反馈调节 |
Advances in research on intronic miRNAs feedback regulation of their host genes |
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| HUANG Bao-Chun,CAO Guo-Jun,SHAO Ning-Sheng.Advances in research on intronic miRNAs feedback regulation of their host genes[J].Bulletin of the Academy of Military Medical Sciences,2009,33(6):580-582. |
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| Authors: | HUANG Bao-Chun CAO Guo-Jun SHAO Ning-Sheng |
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| Institution: | ( Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China) |
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| Abstract: | miRNAs were discovered less than a decade ago, and have emerged as important regulators of gene expression in mammals. A large number of miRNAs have been identified to be located within the intronic regions of protein-encoding genes(host genes) and called intronic miRNAs. The intronic miRNAs may play a key role in regulating the expression and function of their host genes due to the fact that most of them are co-expressed with the host genes. In this paper, the recent advances on the research on potential relationship between intronic miRNAs and their host genes are reviewed. |
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| Keywords: | miRNA miRNA introns host gene feedback regulation |
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