| 献血者血清抗-HCV阳性与ALT活性的关系 |
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| 引用本文： | 钟土泉,张小云. 献血者血清抗-HCV阳性与ALT活性的关系[J]. 中国热带医学, 2005, 5(4): 819-820 |
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| 作者姓名： | 钟土泉 张小云 |
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| 作者单位： | 1. 湛江市中心血站检验科,广东,湛江,524002
2. 湛江中心人民医院检验科,广东,湛江,524000 |
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| 摘 要： | 目的 分析献血者血清抗-HCV抗体及丙型肝炎病毒核酸（HCVRNA）含量与ALT的关系。方法 采用ELISA法检测抗-HCV抗体。阳性标本用荧光PCR试剂盒测定HCVRNA，分析ALT活性与HCVRNA水平的关系。结果 83份抗-HCV抗体阳性标本经PCR检测后有37份标本含HCVRNA，HCVRNA拷贝量与ALT活性呈正相关，且标本的HCVRNA含量越多，ALT活性也越高（P〈0．01）。结论 献血者中筛查ALT并结合PCR技术，能减少HCV经血传播的危险。
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| 关 键 词： | 抗-HCV 丙型肝炎病毒核酸 丙氨酸氨基转移酶 |
| 文章编号： | 1009-9727（2005）04-819-02 |
| 收稿时间： | 2005-04-15 |
| 修稿时间： | 2005-04-15 |
The relationship between anti-HCV positive and the activity of ALT in serum of blood donors |
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| ZHONG Tu-quan,ZHANG Xiao-yun. The relationship between anti-HCV positive and the activity of ALT in serum of blood donors[J]. China Tropical Medicine, 2005, 5(4): 819-820 |
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| Authors: | ZHONG Tu-quan ZHANG Xiao-yun |
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| Affiliation: | Zhanjiang Municipal Central Blood Station, Zhanjiang 524002, Guangdong, P. R. China |
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| Abstract: | Objective To investigate the relationship betweem serum virus RNA and ALT levels in anti - HCV positive samples of donors. Methods Hepatitis C virus fluorescence PCR diagnostic kit was carried out on the anti - HCV positive samples in order to reveal any possible relationship between HCV RNA and ALT levels. Results 37 samples were tested positive for HCV RNA a-mong 83 anti - HCV positive samples.The more copies of HCV RNA in the blood samples,the higher the ALT levels (P < 0.01). Conclusion The combination of ALT testing with HCV RNA PCR for screening donors' blood can reduce the risk of transmission of HCV through blood transfusion. |
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| Keywords: | Anti - HCV HCV RNA Alanine aminotransferase |
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