Effect of dietary curcumin and dibenzoylmethane on formation of 7,12- dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice |
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Authors: | Huang MT; Lou YR; Xie JG; Ma W; Lu YP; Yen P; Zhu BT; Newmark H; Ho CT |
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Institution: | Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08854-8020, USA. |
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Abstract: | Female Sencar mice (6 weeks old) were administered 1 mg of 7,12-
dimethylbenza]anthracene (DMBA) by oral gavage once a week for 5 weeks. At
20 weeks after the first dose of DMBA, 68% of mice developed mammary tumors
(the average 1.08 tumors per mouse) and 45% had lymphomas/leukemias.
Feeding 1% dibenzoylmethane (DBM) in AIN 76A diet, starting at 2 weeks
before the first dose of DMBA and continuing until the end of the
experiment, inhibited both the multiplicity and incidence of DMBA-induced
mammary tumor by 97%. The incidence of lymphomas/leukemias was completely
inhibited by 1% DBM diet. In contrast, feeding 2% curcumin diet had little
or no effect on the incidence of mammary tumors, and the incidence of
lymphomas/leukemias was reduced by 53%.
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