| 氧化苦参碱和槐定碱对癫痫的比较研究 |
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| 引用本文： | 张琳娜,王媛,陈晓霞,李玉香,段慧云,白洁.氧化苦参碱和槐定碱对癫痫的比较研究[J].宁夏医学杂志,2009,31(8):676-678. |
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| 作者姓名： | 张琳娜 王媛 陈晓霞 李玉香 段慧云 白洁 |
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| 作者单位： | 宁夏医科大学,宁夏,银川,750004 |
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| 基金项目： | 1.宁夏自然科学基金(NZ0784) 2.宁教高[2006]237号 |
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| 摘 要： | 目的探讨氧化苦参碱和槐定碱对癫痫的作用。方法大鼠腹腔注射青霉素制作癫痫模型，以苯巴比妥钠作阳性对照，观察氧化苦参碱和槐定碱的不同作用。结果氧化苦参碱中、高剂量组和槐定碱低剂量组可延长癫痫大鼠惊厥潜伏期，明显减轻大鼠痫样发作程度；氧化苦参碱低、中、高剂量组和槐定碱低剂量组对大鼠皮层脑电图有明显改变；在青霉素致痫后，光、电镜观察可见神经细胞肿胀、细胞器损伤等改变，使用氧化苦参碱和槐定碱后神经元细胞肿胀明显减轻，细胞器等损伤能够得到改善。结论不同剂量的氧化苦参碱和槐定碱对癫痫具有不同的影响。
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| 关 键 词： | 氧化苦参碱 槐定碱 癫痫 脑电图 |
An experimental study on Oxymartrine and Sophoridine in the seizure rats induced by Penicillin |
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| ZHANG Lin-na,WANG Yuan,CHEN Xiao-xia,et al..An experimental study on Oxymartrine and Sophoridine in the seizure rats induced by Penicillin[J].Ningxia Medical Journal,2009,31(8):676-678. |
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| Authors: | ZHANG Lin-na WANG Yuan CHEN Xiao-xia |
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| Institution: | Ningxia Medical University;Yinchuan 750004;China |
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| Abstract: | Objective To explore the different role of Oxymartrine(OMT)and Sophoridine(SOP).Methods A model of epilepsy were established induced by administration of 800 million U/kg Penicillin and observed pharmacological effects of OMT and SOP.Result The middle and high dose of OMT and the low dose of SOP obviously prolonged the latencies of epileptic seizure,and reduced seizure degree;the low,middle and high dose of OMT and the low dose of SOP obviously changed seizure EEG;after epilepsy induced by penicillin,we obs... |
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| Keywords: | Oxymartrine Sophoridine Seizure EEG |
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