中药麦冬脂溶性化学成分的研究

 目的　研究中药麦冬(Ophiopogonjaponicus)块根的脂溶性成分,为全面反映麦冬的化学成分提供依据。方法　利用硅胶和SephadexLH-20等柱色谱进行分离,用化合物的波谱数据鉴定其结构。结果　从麦冬块根的醋酸乙酯部位分得16个脂溶性成分,其中包括7个高异黄酮类成分即甲基麦冬黄烷酮A(Ⅰ),甲基麦冬黄烷酮B(Ⅱ),甲基麦冬黄酮A(Ⅲ) ,甲基麦冬黄酮B(Ⅳ),2′-羟基甲基麦冬黄酮A(Ⅴ),6-醛基异麦冬黄烷酮A(Ⅵ),5,7-dihydroxy-8-methoxy-6-methyl-3-(2′-hydroxy-4′-methoxybenzyl)chroman-4-one(Ⅶ) ;2个蒽醌类成分即大黄酚(Ⅷ)和大黄素(Ⅸ);3个酚酸类成分即香草酸(Ⅹ),对羟基苯甲醛(Ⅺ)和对羟基反式丙烯酸(Ⅶ);2个萜类成分即龙脑葡萄糖苷(Ⅷ)和齐墩果酸(XIV);2个有机酸类成分即壬二酸(XV)和正二十三烷酸(XVI)。结论　化合物IV为首次从该植物中分得,化合物Ⅷ～Ⅻ,XIV～XVI为首次从沿阶草属植物中分得。蒽醌类,三萜类以及酚酸类为首次从沿阶草属植物中分得的化合物类型。

Studies on the liposoluble components from tuber of Ophiopogon japonicus

OBJECTIVE To investigate the liposoluble components from the tuber of Ophiopogon japonicus. METHODS The compounds were isolated by column chromatography with silica gel and Sephadex LH-20 and the structures were elucidated by spectras′analysis.RESULTS Sixteen compounds were obtained as 7 homoisoflavones,2 anthraquinones,3 phenolic acids,2 terpenes and 2 fatty acids. Their structures were identified as methylophiopogonanone A(Ⅰ), methylophiopogonanone B(Ⅱ), methylophiopogonone A(Ⅲ), methylophiopogonone B(Ⅳ),2′-hydroxy methylophiopogonone A(Ⅴ),6-aldehydo-isoophiopogo nanone A(Ⅵ),5,7-dihydroxy-8-methoxy-6-methyl-3-(2′-hydroxy-4′-methoxybenzyl)chroman-4-one(Ⅶ), chrysophenol(Ⅷ),emodin(Ⅸ),vanillic acid(Ⅹ),P-hydroxy benzaldenhyde (Ⅺ),P-trans-coumarinic acid(Ⅻ),l-borneol-β-D-glucopyranoside(XIII),oleanolia acid(XIV),azelaic acid(XV) and n tricosanoic acid(XVI).CONCLUSION The compound Ⅳ,Ⅷ～Ⅻ and XIV～XVI were isolated from O.japonicus and the genus Ophiopogon for the first time, respectively.The types of anthraquinone,phenolic acid and triterpene were firstly obtained from the genus.