北京市海淀区妊娠期糖尿病和健康孕妇膳食频次与头发中锡水平的关联研究

目的 了解北京市海淀区妊娠期糖尿病(GDM)孕妇与健康孕妇头发中锡元素(Sn)的浓度分布及差异,并探讨锡暴露与膳食频次的关系.方法 本研究为巢式病例对照设计,研究对象为2017年10月—2018年10月在北京市海淀区妇幼保健院建档并自愿参加孕期队列的孕早期妇女,募集时问卷调查收集一般人口学特征和膳食频次,并采集头发标本...

Association between dietary frequency and Stannum level in hair of pregnant women with gestational diabetes mellitus and healthy women in Haidian district,Beijing

Objective To describe and compare the concentration of Stannum(Sn)in the hair of gestational diabetes mellitus(GDM)women and healthy pregnant women in Haidian district of Beijing,and explore the relationship between Sn and dietary intake frequency.Methods Subjects were early pregnant women who filed in the Haidian District Maternal and Child Health Hospital in Beijing from October 2017 to October 2018 and volunteered to participate in the birth cohort.Questionnaires were used to collect general demographic characteristics and dietary frequency,and hair samples were also collected.A 75-g oral glucose tolerance test was performed between 24-28 weeks of pregnancy.This study was a nested case-control design.The control group was randomly selected according to the ratio of case∶control=1∶1.A total of 338 cases and 343 controls were included in analysis.Sn in hair was detected by inductively coupled plasma mass spectrometer.Results Sn concentrations(median)of GDM group and control group were 0.17μg/g and 0.14μg/g,respectively.Sn was significantly higher in GDM group than control group;there was no significant difference of Sn concentration distribution among different groups in the case or control group.Eating fried foods is a risk factor for Sn exposure,while meat,seafood,fresh vegetables,fresh fruits,barbecue,preserved foods,desserts and carbonated beverages were not related to Sn.Conclusion Sn exposure of pregnant women in Haidian district of Beijing was relatively lower,but Sn of GDM group was higher than that of control group.Eating fried food was a risk factor for Sn exposure,and no other dietary intake frequency were found to be related to Sn exposure of pregnant women.