细胞衰老及衰老相关分泌表型在椎间盘退变中的研究进展

椎间盘细胞在不断分裂增殖和外界不利因素的持续刺激下极易发生老化。衰老细胞在影响椎间盘结构和功能同时异常表达衰老相关分泌表型(SASP),通过分泌促炎因子、趋化因子、生长因子和蛋白酶类等物质加速椎间盘退变的进程。目前已证实抗衰老治疗在椎间盘退变疾病中有很好的应用前景,包括减少衰老细胞发生、细胞移植抗衰老治疗等,特别是近些年靶向干预SASP抗衰老治疗受到学者广泛关注。本文就近年来细胞衰老和SASP在椎间盘微环境中的作用机制及相关干预措施进行综述。

Research progress of cell senescence and senescence-associated secretory phenotype in intervertebral disc degeneration

Intervertebral disc cells are prone to ageing under the stimulation of splitting proliferation and unfavorable external factors.The structure and function of intervertebral disc are affected by senescent cells,which express the senescence-related secretory phenotype(SASP),and accelerate the process of intervertebral disc degeneration by secreting pro-inflammatory factors,chemokines,growth factors and proteases.At present,anti-aging therapy has been proved to have a good application prospect in intervertebral disc degeneration,including reducing the occurrence of senescent cells,anti-aging therapy by cell transplantation,etc.,especially in recent years,targeted intervention on SASP has been widely concerned by scholars.In this paper,the mechanism of cellular senescence and SASP in the intervertebral disc microenvironment and related intervention measures in recent years are reviewed.