Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype

Authors:	P.P. Landburg T. Teerlink B.J. Biemond D.P.M. Brandjes F.A.J. Muskiet A.J. Duits J.B. Schnog

Affiliation:	1. Inter-university Laboratory of Human Movement Science EA7424, Vascular biology and Red Blood Cell Team, University Claude Bernard Lyon 1, University of Lyon, Villeurbanne, France;2. Laboratory of Excellence “GR-Ex”, Paris, France;3. Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA;4. Center for Translational and International Hematology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA;5. Institut Universitaire de France, Paris, France;6. Laboratory of Biochemistry and Molecular Biology, Hospital Edouard Herriot, Lyon, France;1. Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Israel;2. Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel;3. Department of Internal Medicine, Hospital Universitario de Santa Lucía, Cartagena, Spain;4. Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain;5. Department of Internal Medicine, Hospital Infanta Sofía, Madrid, Spain;6. Department of Internal Medicine, Hospital Universitario Puerto Real, Cádiz, Spain;7. Department of Internal Medicine, Hospital Germans Trias i Pujol, Badalona, Spain

Abstract:	Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related complications. Plasma ADMA and associated parameters were determined in 52 HbSS/HbSβ⁰-thalassemia and 24 HbSC/HbSβ⁺-thalassemia patients. As expected ADMA levels were higher in HbSS/HbSβ⁰-thalassemia patients with PHT (p = 0.018), but also in those with other hemolysis-associated complications such as leg ulcers (p = 0.012), cholelithiasis (p = 0.008) and priapism (p = 0.02) compared with counterparts without these complications. ADMA levels did not differ between patients with and without other disease related complications such as retinopathy and avascular osteonecrosis. Higher ADMA concentrations therefore seem to be associated to the hemolytic phenotype of SCD.

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