| 长链非编码RNA-linc00092在胃癌组织的表达及其临床意义 |
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| 引用本文： | 罗俊,马阿火,杨燕飞,王海峰,邵春燕. 长链非编码RNA-linc00092在胃癌组织的表达及其临床意义[J]. 中华实验外科杂志, 2021, 0(3): 439-441 |
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| 作者姓名： | 罗俊 马阿火 杨燕飞 王海峰 邵春燕 |
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| 作者单位： | 绍兴市人民医院消化内科;绍兴市人民医院胃肠外科;苏州市相城人民医院消化内科 |
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| 摘 要： | 目的:观察长链非编码RNA(lncRNA)-linc00092在胃癌组织中的分布特点，探讨linc00092表达高低对胃癌患者多种生存特点的影响，并对其与胃癌常见临床病理学特点的相关性进行分析。方法:在13例胃癌患者中，分析癌组织和正常组织中的linc00092的表达差异；在线生存数据库中，分析胃癌组织中的linc00...
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| 关 键 词： | 胃癌 长链非编码RNA 生存 |
Long non-coding RNA-linc00092 as a poor prognostic factor for gastric cancer |
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| Luo Jun,Ma Ahuo,Yang Yanfei,Wang Haifeng,Shao Chunyan. Long non-coding RNA-linc00092 as a poor prognostic factor for gastric cancer[J]. Chinese Journal of Experimental Surgery, 2021, 0(3): 439-441 |
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| Authors: | Luo Jun Ma Ahuo Yang Yanfei Wang Haifeng Shao Chunyan |
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| Affiliation: | (Department of Gastroenterology,Shaoxing People′s Hospital,Shaoxing 312000,China;Department of Gastrointestinal Surgery,Shaoxing People′s Hospital,Shaoxing 312000,China;Department of Gastroenterology,Suzhou Xiangcheng People′s Hospital,Suzhou 215131,China) |
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| Abstract: | Objective To evaluate the expression levels of linc00092 in gastric cancer and analyze the correlation between linc00092 and clinicopathological features,and effects of linc00092 on overall survival(OS),first progression(FP)and post-progression survival(PPS)in gastric cancer patients.Methods In 13 gastric cancer patients,the expression levels of linc00092 in gastric cancer samples and normal tissues were detected.Real-time quantitative polymerase chain reaction(Real-time PCR)was utilized to analyze levels of linc00092.The correlation between linc00092 and the clinicopathological features in gastric cancer was analyzed.Online Kaplan-Meier Plotter(KM)database was used to evaluate the effects of linc00092 on survival of gastric cancer patients.Results The linc00092 levels were higher in cancer samples than those in normal ones in gastric caner(fold change 2.316,t=3.195,P<0.01).Linc00092 levels were correlated to grade,tumor infiltration and lymph node metastasis positively(χ2=4.712,8.478,7.608,P<0.05).OS rate of gastric cancer patients with higher levels of linc00092 were shorter than those with lower levels of linc00092 expression in all patients,stageⅢ-Ⅳ,female patients,male patients,surgery alone,human epidermal growth factor receptor 2(Her-2)negative and Her-2 positive groups(P<0.05).Similar trends were also observed in FP analysis in all patients,stageⅡ-Ⅲ,Her-2 negative and Her-2 positive groups(P<0.05),and in PPS analysis in all patients,stageⅠ-Ⅳ,female patients,male patients,surgery alone,Her-2 negative and Her-2 positive groups(P<0.05)Conclusion Linc00092 level was higher in gastric cancer tissues,and correlated to grade,tumor infiltration and lymph node stage positively.Higher expression of linc00092 is related to shorter survival in gastric cancer. |
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| Keywords: | Gastric cancer Long non-coding RNA Survival |
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