Sesquiterpenoids from the resinous exudates of Commiphora myrrha and their neuroprotective effects |
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| Authors: | Xu Jing Guo Yuanqiang Li Yushan Zhao Peng Liu Cuizhou Ma Yonggang Gao Jie Hou Wenbin Zhang Tiejun |
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| Institution: | College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China. |
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| Abstract: | Ten new furanosesquiterpenoids, myrrhterpenoids A-J (1- 10), together with eight known analogues (11- 18), were isolated from the resinous exudates of COMMIPHORA MYRRHA. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by the ChemDraw 3D modeling using MM2. All isolated furanosesquiterpenes showed neuroprotective effects against MPP (+)-induced neuronal cell death in SH-SY5Y cells. |
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