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Metastatic vulvar Paget's disease responding to combination chemotherapy: case report |
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| Authors: | Y Yokoyama M Mabuchi I Kawabata K Niwa K Shimokawa T Tamaya |
| Affiliation: | Department of Obstetrics and Gynecology, Gifu University School of Medicine. |
| Abstract: | No effective chemotherapy for advanced extramammary Paget's disease has yet been established. A case of vulvar Paget's disease with systemic metastases was treated with a mitomycin C, vincristine and cisplatin combination chemotherapy, by which the vulvar lesion and serum CEA were clearly decreased. After surgery and 5-fluorouracil treatment, a similar combination chemotherapeutic regimen was administered to treat a recurrence, however, the lesions became resistant. |
| Keywords: | Extramammary Paget's disease Carcinoembryonic antigen Drug therapy Cytokeratin |
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