| 四种8-氨喹啉衍生物抗利什曼原虫作用初步研究 |
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| 引用本文： | 瞿靖琦,管立人,高金桐.四种8-氨喹啉衍生物抗利什曼原虫作用初步研究[J].药学学报,1963,10(1):47-50. |
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| 作者姓名： | 瞿靖琦 管立人 高金桐 |
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| 作者单位： | 中国医学科学院寄生虫病研究所，中国医学科学院寄生虫病研究所，山东寄生虫病防治研究所 |
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| 摘 要： | 四种8-氨喹啉类衍生物中,(口派)嗶嗪喹啉和伯氨喹啉无论对体内和体外黑热病原虫均具有良好的杀灭作用,而赫诺奇特和氧氮六环基喹啉则无显著效果。
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| 收稿时间： | 1962-04-29 |
THE LEISHMANICIDAL EFFECTS OF FOUR 8-AMINOQUINOLINE DRUGS, A PRELIMINARY STUDY |
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| Qu JING-QI GUAN LI-REN GAO JING-TONG.THE LEISHMANICIDAL EFFECTS OF FOUR 8-AMINOQUINOLINE DRUGS, A PRELIMINARY STUDY[J].Acta Pharmaceutica Sinica,1963,10(1):47-50. |
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| Authors: | Qu JING-QI GUAN LI-REN GAO JING-TONG |
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| Abstract: | Four groups of hamsters infected with Leishmania donovani were treated with primaquine, 8-piperazinyl aminoquinoline, chinocide, and 8-morpholinyl aminoquinoline per os. The count of parasites in the smears of liver and spleen was made 3 clays after the completion of treatment for evaluating the therapeutic action. It was shown that 8-Fiperazinyl aminoquinoline had a high, and primaquine a low, therapeutic activity, while the other two compounds were ineffective. Various concentrations of 8-piperazinyl aminoquinoline anti primaquine in normal saline were used in vitro for determining the leishmanicidal effect on leptomonas of Leishmania donovani. It was found that the two derivatives exerted a complete killing effect in 48 hours at the concentrations of 1:4,000 and 1:6,000 respectively. |
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