T‐cell‐rich HLA‐haploidentical hematopoietic stem cell transplantation for relapsed/refractory pediatric Philadelphia chromosome‐positive acute lymphoblastic leukemia without posttransplant tyrosine kinase inhibitor therapy |
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| Authors: | Hideki Sano Kazuhiro Mochizuki Mitsuko Akaihata Shogo Kobayashi Hitoshi Ohto Atsushi Kikuta |
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| Institution: | 1. Department of Pediatric Oncology, Fukushima Medical University Hospital, Fukushima, Japan;2. Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan |
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| Abstract: | Intensive chemotherapy with tyrosine kinase inhibitor (TKI) improves the prognosis of patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph‐ALL). However, the prognosis of cases of relapsed or refractory Ph‐ALL remains poor. Here, we aimed to assess the efficacy of T‐cell‐rich HLA‐haploidentical hematopoietic stem cell transplantation (TCR‐haplo‐HSCT) in eight patients with relapsed or refractory pediatric Ph‐ALL. Transplant‐related mortality was observed in two patients. All patients discontinued TKI after receiving TCR‐haplo‐HSCT. The 3‐year probability of overall survival and event‐free survival was 75.0 and 62.5%, respectively. These results indicate the efficacy of TCR‐haplo‐HSCT for relapsed/refractory pediatric Ph‐ALL. |
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| Keywords: | acute lymphoblastic leukemia children haploidentical hematopoietic stem cell transplantation Philadelphia chromosome relapse tyrosine kinase inhibitor |
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