Outcomes of children with rhabdomyosarcoma treated with intensive chemotherapy,surgery, and radiotherapy through a period of protocol revision at a South African center, 1990–2010 |
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| Authors: | Marc Hendricks Jeanette Parkes Komala Pillay Alastair Millar Ann van Eyssen Alp Numanoglu Alan Davidson |
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| Affiliation: | 1. Haematology Oncology Service, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa;2. Department of Radiation Oncology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa;3. Department of Anatomical Pathology, National Laboratory Health Services, University of Cape Town, Cape Town, South Africa;4. Department of Paediatric Surgery, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa |
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| Abstract: | A total of 75 children with biopsy‐proven rhabdomyosarcoma were treated at our institution between 1990 and 2010. Five‐year overall survival (OS) for the entire cohort was 58.7%. OS by stage was as follows: Stage 1 (80%), Stage 2 (80%), Stage 3 (54.1%), and Stage 4 (38.5%). There was a trend to suggest that revision of treatment approaches improved crude survival over time: pre‐2003 (OS 42.1%); 2003–2005 (OS 50.0%); 2005–2010 (OS 60.8%). |
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| Keywords: | middle‐income countries rhabdomyosarcoma |
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