颅脑损伤患者血浆胃动素、血清胃泌素含量变化的观察

目的　探讨颅脑损伤患者血浆胃动素 (MTL)、血清胃泌素 (GAS)水平变化。方法　将颅脑损伤患者分为轻度损伤组和重度损伤脑出血组 ,用放射免疫分析法测定其入院当日、第 5d、第 15d血浆MTL、血清GAS水平 ,并与正常对照组比较。结果　入院当日轻度损伤组和重度损伤脑出血组患者MTL、GAS均较对照组明显升高 (P <0 0 5 ,P <0 0 1) ;第 5dMTL、GAS与入院当日比较 ,轻度损伤组无显著性差异 (P >0 0 5 ) ,而重度损伤脑出血组明显升高 (P <0 0 5 ) ;第 15d轻度损伤组MTL、GAS降至正常 (与对照组比较P >0 0 5 ) ,而重度损伤脑出血组MTL、GAS升高更加显著 (与入院当日比较P <0 0 1)。结论　颅脑损伤患者血MTL、GAS水平越高 ,表明脑损伤越严重 ,测定血浆MTL、血清GAS对颅脑损伤患者的治疗及预后的观察具有重要的临床价值。

The Level Change of Plasma Motilin and Serum Gastrin in Patients with Craniocerebral Trauma

Objective To explore the level change of plasma motilin and serum gastrin in the patients with craniocerebral trauma. Methods The patients with craniocerebral trauma were divided into mild injury group and severe injury group. The levels of plasma motilin and serum gastrin were measured using radioimmunoassay at the first day, 5th day,and 15th day of hospitalization.Results At the first day of hospitalization, the levels of plasma motilin and serum gastrin in the two injury groups were significantly higher than those in the control group; at the 5th day,there is no obvious change of plasma motilin and serum gastrin(P>0.05)in the mild group compared with at the first day, but an obvious rise(P<0.05)in severe injury group; at the 15th day, the levels of plasma motilin and serum gastrin in the mild injury group decreased to the normal range(P>0.05), while continued to increase in the severe group(P<0.01). Conclusion The levels of plasma motilin and serum gastrin in the patients with craniocerebral trauma were positively related with the injury degree of brain. The detection of plasma motilin and serum gastrin will be helpful to treatment and prognosis evaluation of the patients with craniocerebral trauma.