| 白细胞介素6基因转移的白血病细胞体内诱导小鼠免疫功能的实验研究 |
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| 引用本文： | 葛林阜,曹雪涛,于益芝,郑玲莉,周正芳,徐志工. 白细胞介素6基因转移的白血病细胞体内诱导小鼠免疫功能的实验研究[J]. 中华血液学杂志, 1995, 0(6) |
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| 作者姓名： | 葛林阜 曹雪涛 于益芝 郑玲莉 周正芳 徐志工 |
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| 作者单位： | 第二军医大学免疫学教研室，济南军区总医院血液科 |
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| 基金项目： | 国家自然科学基金,上海科技启明星计划 |
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| 摘 要： | 作者观察了人白细胞介素６（ＩＬ－６）基因转移的、能高分泌ＩＬ－６的ＦＢＬ－３红白血病细胞对机体抗肿瘤免疫功能的影响。结果发现，高分泌ＩＬ－６的红白血病细胞接种到小鼠体内后，能显著提高小鼠脾脏的细胞毒性Ｔ淋巴细胞、ＮＫ活性及ＩＬ－２诱导的ＬＡＫ活性，小鼠脾细胞诱生的ＩＬ－２、肿瘤坏死因子和粒－巨噬细胞系集落刺激因子水平亦增高，腹腔巨噬细胞杀伤活性明显增强。结果表明，高分泌ＩＬ－６的ＦＢＬ－３红白血病细胞体内接种后能显著地增强机体的抗肿瘤免疫功能。研究结果为白血病的生物治疗以及ＩＬ－６基因转移的新型瘤苗的应用研究提供了实验依据。
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| 关 键 词： | 白细胞介素6，基因治疗，白血病，细胞因子 |
EXPERIMENTAL STUDY ON THE IN Vlvo INDUCTONOF IMMUNE FUNCTION BY IL-6 GENE-TRANSFECTEDMOUSE LEUKEMIA CELLS |
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| Ge Linfu, Cao Xuetao, Yu Yizhi,et al.. EXPERIMENTAL STUDY ON THE IN Vlvo INDUCTONOF IMMUNE FUNCTION BY IL-6 GENE-TRANSFECTEDMOUSE LEUKEMIA CELLS[J]. Chinese Journal of Hematology, 1995, 0(6) |
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| Authors: | Ge Linfu Cao Xuetao Yu Yizhi et al. |
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| Affiliation: | Ge Linfu, Cao Xuetao, Yu Yizhi, et al. |
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| Abstract: | n order to investigate the anti-leukemia effect ofthe tumor vaccine, we transfected the mouse FBL-3leukemia cell with IL-6 gene and selected a clone se-creting the highest level of IL-6 . It was found that af-ter inoculation of the IL-6 secreting cell clone into themouse, its CTL, NK and IL-2 induced LAK activitieswere all significantly augmented. Furthermore, thelevels of IL-2, TNF and GM-CSF secreted by murinesplenocyte were also increased , and the cytotoxicity ofperitoneal macrophage was significantly augmented.These results suggested that inoculation of IL-6 secret-ing leukemia cells can effectively enhance the host anti-leukemia immunological functions. |
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| Keywords: | Interleukin-6 Gene therapyLeukemia Cytokine |
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