延胡索乙素和延胡索炮制品提取物的药动学比较

目的:研究延胡索乙素、延胡索生品和醋炙品提取物在大鼠体内的药动学。方法:高效液相色谱法测定血浆中延胡索乙素的血药浓度,采用3p97药动学处理软件,计算药动学参数,CmaxTmax采用实测值。结果:延胡索乙素单体、延胡索药材生品和醋炙品T1/2为(5.66±1.92)、(4.24±1.54)、(4.35±1.34)h;Tmax为(1.5±0.5)、(1.0±0.55)、(0.5±0.68)h;Cmax为(0.71±0.29)、(0.37±0.11)、(0.67±0.35)μg/ml;AUCo-t为(2.58±0.85)、(1.96±0.69)、(2.95±1.61)μg/ml。结论:延胡索生品和醋炙品均能缩短延胡索乙素的达峰时间,说明其两者能起效迅速。

Comparison of Pharmacokinetics of Tetrahydropalmatine Monomer and Extractive of Corydalis and Corydalis Processed with Vinegar

OBJECTIVE: To investigate the pharmacokinetics of tetrahydropalmatine monomer and extractive of corydalis and corydalis processed with vinegar in rats. METHODS: The plasma concentrations of tetrahydropalmatine were determined by a reversed phase high performance liquid chromatographic. The plasma concentrations-time data were calculated with 3p97 program. RESULTS: The main pharmacokinetic parameters of tetrahydropalmatine monomer and extractive of corydalis and corydalis processesd with vinegar as follows: T(1/2) was (5.66 +/- 1.92), (4.24 +/- l1.54), (4.35 +/- 1.34) h, Tmax was (1.5 +/- 0.5), (1.0 +/- 0.55), (0.5 +/- 0.68) h, Cmax was (0.71 +/- 0.29), (0.37 +/- 0.11), (0.67 +/- 0.35) microg/ml,AUC(o-t), was (2.58 +/- 0.85), (1.96 +/- 0.69), (2.95 +/- 1.61) microg/ml. CONCLUSION: The T(1/2) of corydalis and corydalis processesd with vinegar is more shorter than tetrahydropalmatine monome, the effect of preventing pain is promoted in rats.