自发性高血压大鼠高胰岛素血症对血管反应性的影响及药物干预的实验研究

目的和方法：研究自发性高血压大鼠（ＳＨＲ）及合并高胰岛素血症时血管反应性的差异及血管紧张素转化酶抑制剂（苯那普利，ｂｅｎａｚｅｒｐｒｉｌ）、“九七黄”（复合制剂，Ｊｉｕｑｉｈｕａｎｇ）对其影响。ＳＨＲ喂养高糖饲料形成高胰岛素血症观察ＳＨＲ及ＳＨＲ合并高胰岛素血症时血管对缩血管物质及舒血管物质的反应性改变，及用苯那普利，苯那普利与“九七黄”合用时血管反应性的改变；及各组血液亚硝酸盐（ＮＯ２）、内皮素（ＥＴ）、血栓素（ＴＸＡ２）、前列腺环素（ＰＧＩ２）的变化。结果：高胰岛素血症可使血管对缩血管物质反应性增强，对舒血管物质反应性减弱。苯那普利在降低高胰岛素血症的同时使血管对缩血管物质及舒血管物质的反应性有所改善；但加用“九七黄”后，这种改善作用更显著。结论：高胰岛素血症可使ＳＨＲ血管对缩血管物质反应性增强，对舒血管物质反应减弱。苯那普利、“九七黄”可改善这种异常作用，这些均与体内血管活性物质一氧化氮（ＮＯ）、ＰＧＩ２降低，ＥＴ、ＴＸＡ２升高有关。苯那普利、“九七黄”的改善作用也与ＮＯ、ＰＧＩ２升高，ＥＴ、ＴＡＸ２降低有关。

The effect of hyperinsulinemia in spontaneously hypertensive rats on vascular responsiveness and the effects of drugs

AIM:To investigate variations of vascular responsiveness in spontaneously hypertensive rats(SHR) with or without hyperinsulinemia and the effect of benazerpril and Jiu Qi Huang on it. METHODS:Spontaneously hypertensive rats were fed a diet containing high glucose for 4 weeks to result in hyperinsulinemia. The difference of vascular reactivity of SHR and SHR with hyperinsulinemia were studied.The effect of benazerpril and benazerpril with Jiu Qi Huang on vascular reactivity of SHR with hyperinsulinemia and blood NO,ET TXA 2,PGI 2 were also observed.RESULTS:Hyperinsulinemia resulted in higher vascular reactivity than adrenaline and lower than isoprenaline. Benazerpril decreased hyperinsulinemia and improved vascular responsiveness, but benazerpril with Jiu Qi Huang had even more significant results than those of benazerpril alone.CONCLUSION:Hyperinsulinemia resulted in higher vascular responsiveness of SHR than adrenaline and lower than isoprenaline. Benazerpril,Jiu Qi Huang improved these effects.These effects may be related with NO,PGI 2,ET,TXA 2 in the body.