| 脐血CD3AK细胞治疗难治性恶性淋巴瘤的临床研究 |
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| 引用本文： | 苏毅,赵碧,赵越华,邵文军,郑华金.脐血CD3AK细胞治疗难治性恶性淋巴瘤的临床研究[J].西南国防医药,2001,11(2):91-92. |
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| 作者姓名： | 苏毅 赵碧 赵越华 邵文军 郑华金 |
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| 作者单位： | 成都军区总医院血液科 |
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| 摘 要： | 目的：探讨脐血CD3AK细胞对难治性恶性淋巴瘤的治疗作用。方法：分离脐血单个核细胞，采用Anti-CD3McAb和rⅡ－2C EY YTETG CD3AK细胞。运动MTT法测定CD3AK细胞的杀瘤活性，并采用静脉输注和瘤体内注射治疗难治性恶性淋巴瘤15例。结果：脐血单个核细胞诱生的CD3AK细胞在体外对K562和Raji细胞有明显杀伤作用，治疗15例难治性恶性淋巴瘤，完全缓解4例，部分缓解2例，有效率40％，结论：脐血CD3AK细胞绎难治性淋巴瘤具有较好疗效。
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| 关 键 词： | CD3AK细胞 脐血 恶性淋巴瘤 治疗 |
| 修稿时间： | 2000年10月21 |
CLINICAL EFFECTS OF CD3AK CELLS DERIVED FROM CORD BLOOD ON REFRACTORY LY MPHOMA |
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| Su Yi,Zhao Bi,Zhao Yuehua,Shao Wenjun,Zheng Huajin.CLINICAL EFFECTS OF CD3AK CELLS DERIVED FROM CORD BLOOD ON REFRACTORY LY MPHOMA[J].Medical Journal of National Defending forces in Southwest China,2001,11(2):91-92. |
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| Authors: | Su Yi Zhao Bi Zhao Yuehua Shao Wenjun Zheng Huajin |
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| Institution: | Su Yi,Zhao Bi,Zhao Yuehua,Shao Wenjun,Zheng HuajinDepartment of Hematology,General Hospital of Chengdu Military Command,Chengdu,610083 |
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| Abstract: | Objective To study the clinical effects of CD3 AK cells on refractory lymphoma. Method CD3 AK cells were prepared with monocytes separated from cord blood and then induced by anti - CD3 McAb, rIL - 2 and PHA. The activity of CD3 AK cells was measured with MTT method. Result K562 and Raji cell were killed significantly by CD3 AK cells in vitro. 4 of 15 patients treated with CD3 AK cells alleviated completely and 2 alleviated partially. The total effective rate was 40% . Conclusion: CD3 AK cells derived from cord blood are hopeful to the treatment of refractory lymphoma. |
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| Keywords: | CD_3 AK cell cord blood lymphoma treatment |
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