急性白血病化疗患者抑郁状况调查分析

目的：探讨急性白血病化疗患者的抑郁状况及其影响因素。方法：用抑郁自评量表（serf-rating depression scale，SDS）及自行设计的多项目调查表对81例急性白血病患者进行化疗前后评定。结果：急性自血病患者存在轻重不等的抑郁症状，化疗前占45．5％，化疗后占33．3％。虽然化疗后评分有降低趋势，但化疗前后SDS评分无显著性差异（P〉0．05）。多元线性逐步回归分析提示情绪低落、纳差、易怒、疲乏是影响急性白血病患者抑郁症状的重要因素。结论：抑郁是急性白血病患者普遍存在的症状，并受多种因素影响。因此，在急性白血病患者化疗过程中，选用高效低毒的化疗药物，同时辅助有效心理干预措施，对缓解抑郁情绪可能具有重要意义。

Depression status in patients with acute leukemia treated by chemotherapy

Objective：To determine depressive status and correlated factors in patients with acute leukemia（AL）. Methods： Eighty one hospitalized patients with AL were enrolled in this study. Questionnaires of self - rating depression scale （SDS） and multiple items were given twice to them before and after chemotherapy. Results： The depressive index decreased slightly. The rate of patients with depressive symptoms （SDS 1〉50） was 45.5% before chemo- therapy and 33.3 % after chemotherapy （P 〉 0.05 ）. Linear regression revealed that low spirits, poor food intake, agi- tation, and feckless were risk factors of suffering from depression. Conclusion： Depression appears to be common in patients with AL, and is influenced by multiple factors. Therefore,it is essential to choose the powerful therapeutic a- gents, and carry out psychological interventions during chemotherapy.