CARB-9, a carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139 belongs to a family of cassette-encoded beta-lactamases |
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| Authors: | Petroni Alejandro Melano Roberto G Saka Héctor A Garutti Alicia Mange Laura Pasterán Fernando Rapoport Melina Miranda Mariana Faccone Diego Rossi Alicia Hoffman Paul S Galas Marcelo F |
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| Affiliation: | Servicio Antimicrobianos, INEI-ANLIS "Dr. Carlos G. Malbrán," Av. Velez Sarsfield 563 (1281), Buenos Aires, Argentina. |
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| Abstract: | The gene bla(CARB-9) was located in the Vibrio cholerae super-integron, but in a different location relative to bla(CARB-7). CARB-9 (pI 5.2) conferred beta-lactam MICs four to eight times lower than those conferred by CARB-7, differing at Ambler's positions V97I, L124F, and T228K. Comparison of the genetic environments of all reported bla(CARB) genes indicated that the CARB enzymes constitute a family of cassette-encoded beta-lactamases. |
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