| 正交试验优选脑通颗粒成型工艺 |
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| 引用本文： | 黄勇,石凌云,乔希,王爱民,况时祥,王永林.正交试验优选脑通颗粒成型工艺[J].中国药房,2012(31):2913-2915. |
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| 作者姓名： | 黄勇 石凌云 乔希 王爱民 况时祥 王永林 |
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| 作者单位： | 贵阳医学院药学院;贵阳中医学院附属第二医院 |
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| 基金项目： | 贵州省中药现代化科技产业研究开发专项项目(黔科合农字[2006]5023号);贵州省科技计划课题(黔科合计工字[2009]4001);贵阳市科学技术计划项目([2009]筑科计合同字第9-3-04号) |
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| 摘 要： | 目的:优选脑通颗粒成型工艺。方法:以乙醇浓度、糊精用量、阿司帕坦用量为考察因素,以制粒难易程度、口感、外观、粒度、溶化性及其综合评分为评价指标,采用L(934)正交试验优选成型工艺,并考察颗粒的吸湿性。结果:最佳制粒工艺为乙醇浓度85%,糊精用量为45%,阿司帕坦用量为1%,测得临界相对湿度为70%。结论:本试验结果可为脑通颗粒处方组成的确定及生产环境的控制提供理论依据。
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| 关 键 词： | 脑通颗粒 正交试验 成型工艺 临界相对湿度 |
Optimization of Forming Technology of Naotong Granules by Orthogonal Test |
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| HUANG Yong,SHI Ling-yun,QIAO Xi,WANG Ai-min,WANG Yong-lin.Optimization of Forming Technology of Naotong Granules by Orthogonal Test[J].China Pharmacy,2012(31):2913-2915. |
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| Authors: | HUANG Yong SHI Ling-yun QIAO Xi WANG Ai-min WANG Yong-lin |
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| Institution: | (School of Pharmacy,Guiyang Medi-cal College,Guiyang 550004,China) KUANG Shi-xiang(The Second Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Gui-yang 550001,China) |
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| Abstract: | OBJECTIVE:To optimize the forming technology of Naotong granules. METHODS:The forming technology ofNaotong granules was optimized by L(934) orthogonal design with of ethanol concentration,dosage of dextrin and flavoring agentaspartame(APM) as factors using the degree of difficulty in granulating,taste,appearance,particle size and solubility and othercomprehensive score as indexes. The hygroscopicity of granules was investigated. RESULTS:The proper forming technology wasas follows:the concentration of ethanol was 85%,dosage of dextrin was 45% and APM was 1%,the critical relative humidity wasabout 70%. CONCLUSION:The study provides theory evidence for formulation process of Naotong granules and the control ofproduction environment. |
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| Keywords: | Naotong granules Orthogonal test Forming technology Critical relative humidity |
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