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Radioisotope assessment of heart damage in hypertransfused thalassaemic patients |
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| Authors: | F Scopinaro M Banci A Vania R Tavolaro O Schillaci A Tisei B Werner G Digilio F Ventriglia V Colloridi |
| Institution: | (1) Section of Nuclear Medicine, Department of Experimental Medicine, University  La Sapienza , Rome, Italy;(2) Institute of Paediatrics, University La Sapienza, Rome, Italy;(3) Sez. Medicina Nucleare, c/o Istituto di Radiologia, Policlinico Umberto I, Viale Regina Elena 324, I-00161 Roma, Italy |
| Abstract: | Twenty-five thalassaemic patients treated with repeated blood transfusion (BT) and intensive iron removal therapy were studied by echocardiography and rest/stress equilibrium gated radionuclide angiocardiography (EGNA). Stress left ventricular ejection fraction (LVEF) showed an important negative correlation with number of BTs (r = –0.75). Abnormal values of stress LVEF were measured after 200 BTs: these data demonstrate the effectiveness of stress LVEF in the follow-up of patients who have undergone repeated BTs and the clinical importance of intensive chelation therapy. Peak filling rate did not show diagnostic value in the early detection of iron cardiotoxicity. However, its inverse correlation with BT (r = –60) indicates that iron overload depresses the diastolic parameters. |
| Keywords: | Thalassaemia Iron overload Ejection fraction Equilibrium gated angiocardiography Peak filling rate |
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