Population data for 101 Austrian Caucasian mitochondrial DNA d-loop sequences: Application of mtDNA sequence analysis to a forensic case |
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Authors: | W Parson T J Parsons R Scheithauer M M Holland |
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Institution: | (1) Institute for Forensic Medicine, University of Innsbruck, Muellerstrass 44, A-6020 Innsbruck, Austria, AT;(2) The Armed Forces DNA Identification Laboratory, Armed Forces Institute of Pathology, 1413 Research Blvd., Rockville, Maryland, USA 20 850D3125, US |
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Abstract: | The sequence of the two hypervariable segments of the mitochondrial DNA (mtDNA) control region was generated for 101 random
Austrian Caucasians. A total of 86 different mtDNA sequences was observed, where 11 sequences were shared by more than 1 individual,
7 sequences were shared by 2 individuals and 4 sequences were shared by 3 individuals. One of the four most common mtDNA sequences
in Austrians is also the most common sequence in both U.S. and British Caucasians, found in approximately 3.0% of Austrians,
4.0% of British, and 3.9% of U.S. Caucasians. Of the remaining three common Austrian sequences, one was not observed in either
U.S. or British Caucasians. However, three British Caucasians exhibited a similar sequence type. Therefore, this particular
cluster of sequence polymorphisms may represent a common “European” mtDNA sequence type. In general, Austrian Caucasians show
little deviation from other Caucasian databases of European descent. Finally, mtDNA sequence analysis was applied to a forensic
case, where hairs found at a crime scene matched the control hairs from the suspect.
Received: 30 June 1997 / Received in revised form: 12 November 1997 |
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Keywords: | Mitochondrial DNA Heteroplasmy mtDNA Population frequency estimates Forensic casework |
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