Changes of Thromboxane and Prostacyclin after Smoke Inhalation Injury in Goats

Thirteen goats with chronic lung lymph fistula were inflicted withsmoke inhalation injury.Thromboxane A_2(TXA_2 in terms of thromboxane B_2 orTXB_2)and prostacyclin(PGl_2 in terms of 6-keto-prostaglandin F_(1x)or6-keto-PGF_1x)in plasma,lung lymph and lung tissue were measured withradioimmunoassay(RIA).Extravascular lung water(EVLW),lung lymph flow(QL),the ratio of protein contents between lung lymph and plasma(LIP),hemodynamic parameters,blood gases,platelet and leukocyte counts were alsodetermined.EVLW,QL and L/P increased significantly at the 1st hour,reachedtheir peak values at the 2nd hour,then declined gradually and remained at a levelover the baseline at the 6th hour after injury.TXA_2 and PGl_2 also increasedmarkedly and the.changes of TXA_2 and TXA_2/PGI_2 ratio were in parallel withthose of EVLW,QL and LIP both in degree and in length of time.It is possiblethat the increased TXA_2 and TXA_2/PGI_2 ratio might participate in the formationof permeability pulmonary edema through direct injury and for chemical mediatorsreleased by platelet and leukocyte aggregations promoted by TXA_2.In addition,TXA_2 might also play a role in the early elevation of pulmonary arterial pressure.

Changes of Thromboxane and Prostacyclin after Smoke Inhalation Injury in Goats

Thirteen goats with chronic lung lymph fistula were inflicted with smoke inhalation injury.Thromboxane A_2(TXA_2 in terms of thromboxane B_2 or TXB_2)and prostacyclin(PGl_2 in terms of 6-keto-prostaglandin F_(1x)or 6-keto-PGF_1x)in plasma,lung lymph and lung tissue were measured with radioimmunoassay(RIA).Extravascular lung water(EVLW),lung lymph flow (QL),the ratio of protein contents between lung lymph and plasma(LIP), hemodynamic parameters,blood gases,platelet and leukocyte counts were also determined.EVLW,QL and L/P increased significantly at the 1st hour,reached their peak values at the 2nd hour,then declined gradually and remained at a level over the baseline at the 6th hour after injury.TXA_2 and PGl_2 also increased markedly and the.changes of TXA_2 and TXA_2/PGI_2 ratio were in parallel with those of EVLW,QL and LIP both in degree and in length of time.It is possible that the increased TXA_2 and TXA_2/PGI_2 ratio might participate in the formation of permeability pulmonary edema through direct injury and for chemical mediators released by platelet and leukocyte aggregations promoted by TXA_2.In addition, TXA_2 might also play a role in the early elevation of pulmonary arterial pressure.