Expression of CD80 and CD86 on Peripheral Blood T Lymphocytes in Patients with Systemic Lupus Erythematosus |
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Authors: | Kaori Abe Yoshinari Takasaki Chifuyu Ushiyama Junichi Asakawa Toru Fukazawa Manami Seki Mika Hirashima Makoto Ogaki Hiroshi Hashimoto |
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Affiliation: | (1) Division of Rheumatology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan;(2) Mitsubishi Chemical Corp, Japan |
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Abstract: | CD80 and CD86 were detected in high amounts on circulating T cells in the peripheral blood of some patients with systemic lupus erythematosus (SLE), using flow cytometry and monoclonal antibodies. Patients with other connective tissue diseases did not have a high percentage of T cells expressing CD80 or CD86 in their peripheral blood. CD80 was expressed mainly on CD4 T cells, whereas CD86 was expressed on CD8 T cells, and these two populations were associated with paticular clinical features. These two molecules were expressed on different T-cell populations and might have different roles in the generation and regulation of immune responses. Since high expression of CD86 on T cells was detected much earlier than the appearance of clinical features and a high titer of anti-DNA antibody, it may be a useful parameter for predicting the flare of SLE. |
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Keywords: | CD80 CD86 systemic lupus erythematosus activate T cell |
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