Use of osteogenic bone-marrow precursor cells for reparative osteogenesis in the mandible of experimental animals

Using a model of “bony tissue tunnel defect” produced by the removal of a mandibular incisor in rats, it was found that closing the defect with a bioprosthesis prevented the washing out of osteogenic bone marrow precursor cells, which serve as a substrate for reparative osteogenesis, from the mandibular spongy bone. The reparative process was strongly stimulated if the bioprosthesis contained estrone; in this case, the time required for the tooth socket to be filled with osteogenic tissue was shortened by half. When no bone marrow elements were present in the socket, it was filled with fibrotic connective tissue, the number of bone marrow elements in spongy bone cavities was small, and the mandibular osteogenic tissue underwent atrophy. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 1, pp. 72–75, January, 1995