冠心病患者血清超敏C反应蛋白检测的临床应用

目的探讨及验证血清超敏C反应蛋白(hs-CRP)含量变化在冠心病患者中的临床应用价值。方法采用胶乳增强透射免疫比浊法,定量检测正常对照50例,稳定型心绞痛(SAP)58例,不稳定型心绞痛(UAP)39例,急性心肌梗死(AMI)31例血清hs-CRP含量,分析hs-CRP与冠心病之间的关系,并分析治疗前后hs-CRP含量的变化。结果对照组、SAP组、UAP组和AMI组hs-CRP浓度,分别为(0.98±0.76)mg/L(、3.12±0.71)mg/L(、5.26±1.48)mg/L和(8.83±3.75)mg/L。hs-CRP浓度依次增高,各组间比较都有显著性差异(P<0.01)。SAP组、UAP组和AMI组治疗后hs-CRP浓度分别为(2.56±0.60)mg/L(、3.29±0.95)mg/L、(3.98±1.32)mg/L,与治疗前比较都有显著性差异(SAP组P<0.05,UAP组和AMI组P均<0.01)。结论血清hs-CRP对心血管病变严重程度的预测以及在心血管疾病的预防和疗效观察中有着重要意义。

Clinical application of serum high sensitivity C reactive protein detected in coronary heart disease patients

Objective It is to study and check the clinical application value of the changes of serum high sensitivity C reactive protein(hs-CRP) levels in coronary heart disease(CHD).Methods The contents of serum hs-CRP in normal control (n=50),stable angina pectoris(SAP)(n=58),unstable angina pectoris(UAP)(n=39) and acute myocardial infarction(AMI)(n=31) were quantitatively detected with latex strengthen transmission immunoturbidimetry(ITM).The relation between hs-CRP and CHD and the changes of hs-CRP content before and after treatment were analyzed.Results The concentrations of serum hs-CRP in normal control,SAP,UAP and AMI groups were respectively(0.98±0.76) mg/L,(3.12±0.71) mg/L,(5.26±1.48) mg/L and(8.83±3.75) mg/L.The concentration of serum hs-CRP raised up in turn in the four groups.There were significantly different among the four groups(P<0.01).The concentrations of serum hs-CRP in SAP,UAP and AMI groups after treatment were respectively(2.56±0.60) mg/L,(3.29±0.95) mg/L and(3.98±1.32) mg/L,there were significantly different compared with that before treatment(SAP group P<0.05,UAP group and AMI group P<0.01).Conclusion Serum hs-CRP has important significance in predicting severity degree of cardiovascular lesion,preventing cardiovascular disease and observing curative effect.