凋亡抑制蛋白livin在良性及恶性子宫内膜组织中的表达

目的:探讨livin蛋白在良性及恶性子宫内膜组织中的表达情况。方法:选取子宫内膜腺癌组织44例,子宫内膜不典型增生组织11例,子宫内膜单纯性增生组织9例、增生期内膜10例、分泌期内膜8例,利用免疫组化S-P法染色及显微图像分析系统检测其中livin蛋白的表达。结果:livin在子宫内膜癌中的表达强度明显高于子宫内膜不典型增生及良性子宫内膜(P<0.05),livin的表达在子宫内膜癌不同组织学分级中有显著性差异(P<0.05),在不同分期中无明显差异,且与淋巴转移情况无关。结论:livin可能与肿瘤的的分化有关,可作为反映子宫内膜癌生物学行为的指标,有望成为子宫内膜癌的肿瘤标记物。

Expression of livin in benign and malignant endometrial diseases

Objective:To study the expression of livin in benign and malignant endometrial diseases.Methods:The expressions of livin protein in tissues from 44 cases of endometrial adenocarcinoma,9 simple endometrial hyperplasia,11 endometrial atypical hyperplasia,and 18 normal endometrium were detected by using S-P method and image analysis system.Results:The expressions of livin in endometrial adenocarcinoma were significantly higher than those in simple endometrial hyperplasia and endometrial atypical hyperplasia.There was significant difference in the expression of livin between endometrial adenocarcinomas of different histological grades,but no significant difference was found between endometrial adenocarcinomas of different clinical stages.The expression of livin was not correlated with lymph node metastasis.Conclusion:Livin could be considered as a potential tumor marker and an indicator of the biological behavior of endometrial carcinoma.It may be also an important factor in the immunotherapy of endometrial carcinoma.