Correlation between <Emphasis Type="Italic">Yersinia enterocolitica</Emphasis> and type I collagen reactivity in patients with arthropathies |
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| Authors: | María G Lacoste Héctor Tamashiro Silvia G Correa Ana M S de Guzmán María S Di Genaro |
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| Institution: | (1) Laboratory of Microbiology; Chemistry, Biochemistry and Pharmacy Faculty, National University of San Luis, Chacabuco y Pedernera, San Luis, 5700, Argentina;(2) Public Hospital of San Luis, Héroes de Malvinas 110, San Luis, 5700, Argentina;(3) Immunology, CIBICI (CONICET) Faculty of Chemical Science, National University of Córdoba, Córdoba, 5500, Argentina |
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| Abstract: | We investigated the association with Yersinia infection in patients with arthropathies in our region. To assess the reactivity to articular antigens, the correlation of
anti-Yersinia with anti-type I and type II collagen antibodies was studied. Sera from 124 patients with musculoskeletal symptoms, and 47
synovial fluids (SF) from patients with rheumatoid arthritis (RA), spondyloarthopathies (SpA) or osteoarthritis (OA) were
examined. Immunoglobulins against Yersinia enterocolitica, type I and type II collagens were determined by enzyme-linked immunosorbent assay. Immunoglobulin (Ig) A to Yersinia lipopolysaccharide (LPS) was present in 13/124 sera (10%) and 3/47 SF (6%). By Western blot, IgA to Yersinia outer proteins (Yops) was found in 14/124 sera (11%) and 2/47 SF (4%). Yersinia DNA from SF was not amplified by polymerase chain reaction. We found a significant correlation with anti-collagen type I
but not type II antibodies. These results suggest different reactivity to articular collagen in patients with Yersinia antibodies. |
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| Keywords: | Yersinia enterocolitica Reactive arthritis Collagen Antibodies Lipopolysaccharide |
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