荆花胃康胶丸治疗慢性浅表性胃炎临床研究

目的 观察荆花胃康胶丸治疗慢性胃炎临床疗效.方法 慢性胃炎患者90例,随机分为3组：荆花胃康胶丸大剂量组和小剂量组分别用荆花胃康胶丸160 mg和80 mg,每天3次口服;对照组采用吗丁啉10 mg,每天3次口服;疗程均为14天.观察3组消化不良症状积分、胃排空率及生活质量.结果 治疗后消化不良症状总积分（分）大剂量组（19.97±1.85）和小剂量组（24.40±1.85）均较治疗前（大小剂量组分别为28.33±1.88、27.70±1.68）降低（P＜0.05）;3组生活质量均得到明显改善.荆花胃康胶丸不良反应轻微.结论 荆花胃康胶丸治疗消化不良症状具有良好的临床疗效和安全性,其中大剂量组疗效优于小剂量组.

Clinical Study on Treatment of Chronic Superficial Gastritis with Jinghua Weikang Capsule

OBJECTIVE: To observe the clinical efficacy and safety of Jinghua Weikang Capsule (JWC) on chronic gastritis (CG). METHODS: Ninety patients with CG were randomly divided into 3 groups: the control group treated with domperidone 10 mg, 3 times per day orally, the high and low-dose JWC groups treated with JWC 160 mg and 80 mg respectively 3 times per day. The therapeutic course for all groups was 14 days. Dyspeptic symptom score, gastric emptying rate and quality of life (QOL) in patients were observed. RESULTS: Dyspeptic symptom score was 19.97 +/- 1.85 and 24.40 +/- 1.85 after treatment in high and low-dose JWC groups respectively, lower than that before treatment (28.33 +/- 1.88 and 27.70 +/- 1.68, P <0.05); QOL improved obviously in all the three groups, among which the high-dose JWC group showed the best effect. The adverse reaction of JWC was very mild. CONCLUSION: JWC is an effective and safe drug for alleviating dyspeptic symptoms in patients with CG, its effect is more evident when high dose is applied.